Cytotoxic antibiotic angucyclines and actinomycins from the Streptomyces sp. XZHG99T

Abstract

Three new angucycline-type C-glycosides, grincamycins L–N (1–3), together with the known rabelomycin (4), moromycin B (5), fridamycin D (6), saquayamycin B1 (7), actinomycin X 2 (8), and actinomycin D (9), were isolated from the culture of the soil-derived Streptomyces sp. XZHG99T collected from Color desert, Dengpa District, Tibet. The structures of 1–3 were established by detailed analyses of comprehensive spectroscopic data. Compounds 1–9 exhibited significant cytotoxicity against a panel of human cancer cell lines A549, H157, MCF7, MDA-MB-231, and HepG2, while 4, 8, and 9 showed decent antibacterial activity against Mycobacterium smegmatis and Staphylococcus aureus.