Gesgestational trophoblastic disease with multisistemic complications

Abstract

Gestational trophoblastic disease (GTD) is a condition of uncertain etiology, comprised of a hydatidiform mole (complete and partial), invasive mole, choriocarcinoma, epithelioid trophoblastic tumour and placental site trophoblastic tumour. A partial hydatidiform mole develops when dispermy occurs, and the resulting conceptus is triploidy. A 26-year-old woman (Gravida 2, Para 1, with one previous vaginal delivery of a normal female infant) was 16 weeks pregnant and was scheduled for emergency surgical treatment. She was diagnosed with a hydatidiform mole and eclampsia in our hospital for further treatment. Her pre-treatment beta human chorionic gonadotropin (β-HCG) level was extremely high at 1,082,900 mIU/ml. The obstetricians considered septic complications from the hydatidiform mole and we decided to perform an emergency Sectio parva. Two weeks after delivery, the serum β-hCG level was 16,341 mlU/mL and normalized gradually within two months without any cytotoxic therapy. Partial mole hydatidosa (PMH), as a milder form of GTD, can go along with malignant complications with fatal consequences.