Sweet action: The dynamics of O‐GlcNAcylation during meiosis in mouse oocytes

Abstract

Post-translational modifications regulate mitosis and meiosis. For example, O-GlcNAcylation -the addition of a single N acetyl-glucosamine (O-GlcNAc) to serine or threonine residues- is required for mitotic spindle formation and chromosome segregation; here we show that O-GlcNAcylation occurs in mouse oocytes during meiosis. O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), which respectively adds and removes this modification, are expressed and active during meiosis. This article is protected by copyright. All rights reserved.