Multivalent Sgc8c-aptamer decorated polymer scaffolds for leukemia targeting

Abstract

T-cell acute lymphoblastic leukemia causes a disproportional amount of immature white blood cells in the patients’ bone marrow. The significant undesired side effects associated with traditional chemotherapy treatment prompted us to study a more effective treatment strategy. We decorated polyisocyanopeptide scaffolds with the selective leukemia cell binding aptamer sgc8c and found that the polymers inhibit proliferation by G0/G1-phase arrest, serving as an opportunity for future therapeutic strategies.