Comparative modular analysis of gene expression in vertebrate organs

8Citations
Citations of this article
45Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background: The degree of conservation of gene expression between homologous organs largely remains an open question. Several recent studies reported some evidence in favor of such conservation. Most studies compute organs' similarity across all orthologous genes, whereas the expression level of many genes are not informative about organ specificity.Results: Here, we use a modularization algorithm to overcome this limitation through the identification of inter-species co-modules of organs and genes. We identify such co-modules using mouse and human microarray expression data. They are functionally coherent both in terms of genes and of organs from both organisms. We show that a large proportion of genes belonging to the same co-module are orthologous between mouse and human. Moreover, their zebrafish orthologs also tend to be expressed in the corresponding homologous organs. Notable exceptions to the general pattern of conservation are the testis and the olfactory bulb. Interestingly, some co-modules consist of single organs, while others combine several functionally related organs. For instance, amygdala, cerebral cortex, hypothalamus and spinal cord form a clearly discernible unit of expression, both in mouse and human.Conclusions: Our study provides a new framework for comparative analysis which will be applicable also to other sets of large-scale phenotypic data collected across different species. © 2012 Piasecka et al; licensee BioMed Central Ltd.

Cite

CITATION STYLE

APA

Piasecka, B., Kutalik, Z., Roux, J., Bergmann, S., & Robinson-Rechavi, M. (2012). Comparative modular analysis of gene expression in vertebrate organs. BMC Genomics, 13(1). https://doi.org/10.1186/1471-2164-13-124

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free