Investigating Adipokine levels in the sera of patients with myocardial infarction in a 6-month follow up

Abstract

Adipokines are peptides that regulate endothelial function, inflammation, blood pressure, and hemostasis. We measured Leptin, Adiponectin, Resistin and Adipsin in a cohort of 36 STEMI patients. Serum levels of Adipokines were measured in three time-points by a multiplex assay. A significant difference in Adipsin concentration between day-5 (T5) and day-180 (T180) post-MI was observed. Resistin levels decreased significantly from day 0 (T0) to T5 and T180. Adiponectin/Resistin ratio increased from T0 to T180. Leptin at T0 and T5 were higher in nonsmokers. Adipsin at T0 was inversely correlated with heart rate, respiratory rate and pulse rate. Adiponectin/Resistin ratio at T180 negatively correlated with respiratory-rate. Adiponectin/Resistin ratio at T180 was higher in patients with grade-1 atrioventricular (AV) block. Anteroseptal hypokinesia (AH) correlated with Resistin at T0 and Adipsin at T5 while Leptin at T0 and T5 correlated with AH. Adiponectin/Resistin ratio at T180 was; however, lower in patients with AH. A decreasing trend in Resistin and its T0 association with AH plus correlation of Leptin at T0 and T5 with AH show the effect of Adipokines on mechanical complications after MI. We suggest that Adipokine networks have both beneficial and harmful effects and may be new cardiac biomarkers and/or drug targets.