Antiproliferative triterpenes from Melaleuca ericifolia

Abstract

Three new 28-noriupane triterpenes, 28-norlup-20(29)-en-3β-hydroxy- 17β-hydroperoxide (1), 28-norlup-20(29)-en-3β-hydroxy-17α- hydroperoxide (2), and 205-17β,29-epoxy-28-norlupan-3β-ol (3), were isolated from the leaves of Melaleuca ericifolia along with eight known pentacyclic triterpenes. The structures of the new compounds were elucidated by spectroscopic methods including 1D and 2D NMR spectroscopy and mass spectrometry. The isolated triterpenes were evaluated for antiproliferative activity against the malignant +SA mammary epithelial cell line. © 2008 American Chemical Society and American Society of Pharmacognosy.