The complement system and age-related macular degeneration

Abstract

Purpose: Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world. There are increasing evidences to suggest the complement system may play a significant role on the pathogenesis of AMD. In this review, we summarise the current research in this area. Methods: Review of literature. Results: The complement system is a complex system with several activation pathways. Complement factor H (CFH) polymorphisms has been associated with increase risk of AMD. CFH is an inhibitor protein; the polymorphisms might cause uncontrolled activation by initiation events. Conclusion: Further studies on the molecular basis of the complement-mediated pathogenesis of AMD may offer novel therapy to AMD.