A boron-based synthesis of the natural product (+)-trans- dihydrolycoricidine

Abstract

Diastereoselective diboration results in the highly selective 1,4-dihydroxylation of chiral cyclohexadienes (see scheme). Together with the catalytic enantioselective conjugate allylboration, the diene diboration facilitates the asymmetric synthesis of the cytotoxic agent (+)-trans- dihydrolycoricidine (1). pin=pinacol. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.