Structural and colloidal-chemical characteristics of nanosized drug delivery systems based on pegylated comb-like carriers

Abstract

Novel comb-like polymeric and oligomeric drug carriers combining backbone - copolymers of 5-tertbutylperoxy-5-methyl-1-hexene-3-yne (VEP) and glycidyl methacrylate (GMA) - and side PEG chains of various lengths were synthesized. Nanosized delivery systems containing conjugates of water soluble anticancer drug Doxorubicin were developed. The structures of copolymers and their conjugates with drugs were confirmed by IR-spectroscopy. Structural and colloidalchemical properties of water drug delivery systems were studied using photoluminescent (PL), UV-spectroscopy techniques, surface tension measurements and dynamic light scattering. The scheme of the immobilization of water soluble doxorubicin on developed PEGylated polymeric carriers was assumed. © Riabtseva A., Mitina N., Boiko N., Garasevich S., Yanchuk I., Stoika R., Slobodyanyuk O., Zaichenko A., 2012.