Micellar and interfacial properties of amphiphilic drug–non-ionic surfactants mixed systems: Surface tension, fluorescence and UV–vis studies

Abstract

This study reports the influence of non-ionic surfactants (TX-100 and TX-114) on the CPZ by surface tension, fluorescence and UV–vis spectra to explore their applications as drug delivery vehicles. The synergism is indicated by the values of the interaction parameters and activity coefficients, which are negative and less than unity, respectively. The ideal micellar mole fraction values of CPZ are less than the experimental values, confirming the high contribution of CPZ in mixed systems. The stability of these mixed systems is demonstrated by negative free energies of mixing.