New depot forms of AZT and 3TC based on their phosphonate derivatives: anti-HIV activity and pharmacokinetic parameters

M. K. Kukhanova; M. V. Jasco; A. V. Shipitzyn; D. V. Yanvarev; A. L. Khandazhynskaya

Journal ArticleOPEN ACCESS

New depot forms of AZT and 3TC based on their phosphonate derivatives: anti-HIV activity and pharmacokinetic parameters

Nucleic acids symposium series (2004) (2008) (52) 597-598

DOI: 10.1093/nass/nrn302

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Abstract

New phosphonate depot forms of AZT and 3TC were synthesized and their anti-HIV properties in cell systems, cellular uptake, intracellular transformations and some pharmacokinetic and toxicological data were studied.

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Kukhanova, M. K., Jasco, M. V., Shipitzyn, A. V., Yanvarev, D. V., & Khandazhynskaya, A. L. (2008). New depot forms of AZT and 3TC based on their phosphonate derivatives: anti-HIV activity and pharmacokinetic parameters. Nucleic Acids Symposium Series (2004), (52), 597–598. https://doi.org/10.1093/nass/nrn302

New depot forms of AZT and 3TC based on their phosphonate derivatives: anti-HIV activity and pharmacokinetic parameters

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