Design of orally disintegrating tablet of hydrochlorthiazide and it's evaluation

Abstract

The aim of present work was to show the effect of various superdisintegrant on the disintegration time and in vitro drug release rate. In this study, an attempt had been made to prepare orally disintegrating tablets of the Hydrochlorthiazide using co-processed super disintegrant following direct compression method. Sodium starch glycolate, crospovidone and starch were used in different concentrations as the super disintegrant. The tablets were evaluated for diameter, thickness, hardness, friability, weight variation, wetting time, disintegration time, dispersion time, drug content and in vitro dissolution studies. Friability value of none of the formulation exceeds 0.245 %. The dispersion time of all Formulation were found to be in between 17.95(±0.06) to 55.61(±0.06) seconds. The wetting time of all the tablets was in the range 25.70 - 52.70 seconds. Overall, the formulation A5 containing 4 % w/w of co-processed superdisintegrants (1:1 mixture of crospovidone and sodium starch glycolate) was found to be promising and has shown an in vitro dispersion time 17.95 sec., wetting time 21.14 sec and disintegration time 17.05 sec. Percentage cumulative drug release of formulation A5 was found to be 98.51% that is maximum % drug release than other formulation. Formulation A5 containing 4%w/w of co-processed superdisintegrant (1:1 mixture of Crospovidone and sodium Starch glycolate), using direct compression method was found to be the best formulation that has minimum disintegration time, wetting time hence this formulation was selected for In-vitro dissolution study and more than 95% drug was dissolved within 15 min.