hematological parameters levels study in sickle cell anemia patients in Al-Diwaniyah and Al-Najaf governorates

Abstract

Background: Sickle cell anemia a dangerous genetic disorder  in which the erythrocytes of the body caused by a mutation in the HBB gene in the sixth position of the β chain, there is a change in the composition of hemoglobin due to the presence of sickle hemoglobin (Hbs). Aim of the study: Is to evaluate the hematological parameters levels in sickle cell anemia condition of patients with sickle cell anemia in the governorates Al- Diwaniyah and Al-Najaf Al-Ashraf.  Methods: A total of one hundred and twenty-four subjects were recruited for this study which consists of eighty four sickle cell anemia subjects who (48 males and 36 females) and Forty healthy (20 male and 20 female) subjects as control who matched by age and sex of the patients groups. Conclusion:  The outcomes indicated decrease in the level of RBC, Hb, MPV and HCT, while observed increased in the level of WBC, PLT, RDW-SD, RDW-CD, MCV, MCHC and PDW in sickle cell anemia patients compared with the control groups, however observed no significant in level of MCH  in  sickled patients compared with the control groups.