Studies on Metabolites Produced by Aspergillus terreus var. aureus. I. Chemical Structures and Antimicrobial Activities of Metabolites Isolated from Culture Broth

Abstract

A fungus which was identified as Aspergillus terreus var. aureus showed antifungal and antibacterial activities. Through the investigation of its metabolites, six compounds (1—6) were isolated; emodin (1), dihydrogeodin (2), questin (3), sulochrin (5), the new metabolite 2-(3-chIoro-4-methyl-y-resorcyloyl)-5-hydroxy-m-anisic acid methyl ester (4), which is a monochloro de-rivative of sulochrin (5), and compound (6), the chemical structure of which has not yet been clarified. Dihydrogeodin (2), sulochrin (5), 4 and 6 showed antifungal and antibacterial activities, and 6 had especially strong antifungal activity towards Trichophyton mentagrophytes. © 1983, The Pharmaceutical Society of Japan. All rights reserved.