Tanycytes Regulate Lipid Homeostasis by Sensing Free Fatty Acids and Signaling to Key Hypothalamic Neuronal Populations via FGF21 Secretion

Abstract

In obesity, the increased levels of circulating lipids induce metabolic dysfunction. Thus, it is essential to determine the mechanisms behind fat storage. Here, Geller et al. demonstrate that brain-specific glial cells, the tanycytes, sense circulating lipid levels to regulate body fat storage via the production of Fgf21.