A biomimetic approach to the pyridone rings of the acromelic acids: A concise synthesis of acromelic acid a and an approach to acromelic acid B.

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Abstract

The syntheses of acromelic acid A 1, allo-acromelic acid A 19 and an approach towards acromelic acid B 2 are described. Palladium (0) catalysed cross-coupling reactions were used to generate C-4 catechol precursors and formation of the pyridone rings was investigated using a biomimetic oxidative cleavage - recyclisation strategy.

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Baldwin, J. E., Fryer, A. M., Pritchard, G. J., Spyvee, M. R., Whitehead, R. C., & Wood, M. E. (1998). A biomimetic approach to the pyridone rings of the acromelic acids: A concise synthesis of acromelic acid a and an approach to acromelic acid B. Tetrahedron, 54(26), 7465–7484. https://doi.org/10.1016/S0040-4020(98)00377-9

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