Prostacyclin prevents pericyte loss and demyelination induced by lysophosphatidylcholine in the central nervous system

Abstract

Background: Pericyte damage is closely associated with the progression of neurodegeneration and neuronal dysfunction in the central nervous system (CNS). Results Prostacyclin attenuates pericyte damage following vascular barrier dysfunction in the adult CNS. Conclusion: Prostacyclin therapy diminishes demyelination and neuronal deficits in pathophysiological conditions. Significance: This study provides the first evidence that pericyte protection contributes to attenuate disease progression in adult CNS.