Antigen processing for MHC presentation by autophagy

Abstract

Autophagy delivers cytoplasmic constituents for lysosomal degradation. This catabolic pathway can be used to deliver intracellular antigens for major histocompatibility complex (MHC) class II presentation. In addition, recent evidence suggests that it also facilitates the processing of extracellular antigens for both MHC class I and II presentation. © 2010 Faculty of 1000 Ltd.