A Facile O-Glycosidation using Stannic Chloride

Abstract

Using stannic chloride, O-glycosidation, especially O-glucuronidation of p-nitrophenol, estradiol 17-acetate, estriol 16,17-diacetate, p-nitrobenzyl alcohol, trichloroethanbl was carried out. This method is available for the preparation of some alkyl a- and β-glucuronosides and aryl β-glucuronosides, especially estrogen derivatives which are obtained in comparatively low yield by the Koenigs-Knorr method. Spectral differences of a- and β-anomers obtained were examined. © 1976, The Pharmaceutical Society of Japan. All rights reserved.