Abstract
We hereby present a simple yet novel chemical synthesis of a family of γ-modified ATPs bearing functional groups on the γ-phosphate that are amenable to further derivatization by highly selective chemical manipulations (e.g., click chemistry, Staudinger ligations). A preliminary screen of these compounds as phosphate donors with a typical wild type protein kinase (cdk2) and one of its known substrates p27kip1 is also presented. © 2009 Elsevier Ltd. All rights reserved.
Cite
CITATION STYLE
Lee, S. E., Elphick, L. M., Anderson, A. A., Bonnac, L., Child, E. S., Mann, D. J., & Gouverneur, V. (2009). Synthesis and reactivity of novel γ-phosphate modified ATP analogues. Bioorganic and Medicinal Chemistry Letters, 19(14), 3804–3807. https://doi.org/10.1016/j.bmcl.2009.04.028
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
