Systolic Heart Function, Kidney Filtration and the Number of Coronary Atherosclerotic Plaques in Lean and Overweight Patients

Abstract

The objective of this study was to quantify the number of vessels with stenotic points in the coronary circulation of lean and overweight individuals submitted to coronary angiography and ventriculography to verify the possible associations with glomerular filtration and the systolic ventricular function. Eighty-six patients with a previous history of myocardial ischemia were studied. Two groups were formed: non-elderly (G1), n = 38, 52.8 ± 1.2 years old, and elderly (G2), n = 48, 70.1 ± 1.2 years old. Both groups were divided into 2 subgroups according to the estimated glomerular filtration rate (eGFR): ≥60 and <60 ml/min/m 2. The results showed that G1 had 0.36 ± 0.11 versus 1.25 ± 0.45 stenoses/patient (≥60 vs. <60 ml/min/m 2; p < 0.05, respectively) and G2 had 0.91 ± 0.28 versus 1.83 ± 0.33 stenoses/patient (≥60 vs. <60 ml/min/m 2, respectively). The other variables, such as central and brachial arterial blood pressures, did not manifest significant differences in relation to the eGFR. The following significant correlations were observed: between the quantity of coronary stenotic points and the eGFR (R 2 = 11.2%; r = -0.33; p < 0.001), and between eGFR and the ventricular ejection fraction (R 2 = 5.1%; r = 0.57; p < 0.0001). The ejection fraction correlated significantly with the number of vessels with stenoses in the coronary bed (R 2 = 13.4%; r = -0.36; p < 0.008). In conclusion, although the correlations are considered weak, interrelationships between heart and kidney were demonstrated in this study.