Synthesis and antioxidant and antimicrobial evaluation of novel 4-substituted-1H-1,2,4-triazole derivatives

Abstract

A series of 4-benzyl/phenyl-3-(1-methyl-1H -indole-2-yl)-1H-1,2,4-triazole- 5(4H)-thione (4a,b) and 2- {4-[benzyl/phenyl-5-(substitutedbenzylthio)]-4H -1,2,4-triazole-3-yl}-1-methyl-1H-indole derivatives (5a-p) were synthesized and evaluated for their in vitro scavenging of DPPH and superoxide radical, and lipid peroxidation inhibition effects as well as their antimicrobial properties. DPPH radical scavenging capacity was found to be equipotent with BHT and found in compounds containing 1,2,4-triazole-5(4H) -thione moiety (4a,b). With regard to antimicrobial properties, compound 5k showed slight antimicrobial activity against all the test microorganisms. © TÜBITAK.