Environmental and metabolic sensors that control T cell biology

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Abstract

The T lymphocyte response to pathogens is shaped by the microenvironment. Environmental sensors in T cells include the nutrient-sensing serine/threonine kinases, adenosine monophosphate-activated protein kinase and mammalian target of rapamycin complex 1. Other environmental sensors are transcription factors such as hypoxia-inducible factor-1 and the aryl hydrocarbon receptor. The present review explores the molecular basis for the impact of environmental signals on the differentiation of conventional T cell receptor αβ T cells and how the T cell response to immune stimuli can coordinate the T cell response to environmental cues.

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Ramsay, G., & Cantrell, D. (2015). Environmental and metabolic sensors that control T cell biology. Frontiers in Immunology. Frontiers Media S.A. https://doi.org/10.3389/fimmu.2015.00099

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