AIP1: a new player in TNF signaling

  • Guicciardi M
  • Gores G
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Abstract

Apoptosis signal-regulating kinase 1 (ASK1) is an upstream activator of JNK and p38 MAPK signaling cascades. Evidence now shows that the ASK1-interacting protein, AIP1, plays an important role in TNF-alpha-induced ASK1 activation by facilitating dissociation from its inhibitor.

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Guicciardi, M. E., & Gores, G. J. (2003). AIP1: a new player in TNF signaling. Journal of Clinical Investigation, 111(12), 1813–1815. https://doi.org/10.1172/jci18911

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