Parallel solution synthesis of lavendustin analogs as antileishmanial agents

Abstract

A concise parallel synthesis of 12 lavendustin analogs is described. Starting with differently substituted benzaldehydes, a two-step sequence involving reductive amination and N-benzylation accelerated by microwaves was performed to provide the compounds in excellent yields. The compounds have been assayed in vitro showing activity against Leishmania donovani, the causative agent of visceral leishmaniasis. © ARKAT-USA, Inc.