Pure-shift IMPRESS EXSIDE - Easy measurement of 1H-13C scalar coupling constants with increased sensitivity and resolution

Abstract

The easy-to-interpret and rapid SelEXSIDE NMR experiment for measuring long-range 1H-13C scalar coupling constants nJCH is improved with increased sensitivity and resolution by the incorporation of 'pure-shift' homonuclear decoupling and IMPRESS-Hadamard encoding, with typical increases in signal-to-noise of over 300% and 400% demonstrated for small molecule examples, and narrower linewidths enabling measurement of smaller coupling constants.