Overcoming kinetic barriers of remote electrochemiluminescence on boron-doped diamond via catalytic coreactant oxidation

Abstract

The effectiveness of boron-doped diamond (BDD) as a platform for electrochemiluminescence (ECL) bead-based bioassays is hindered by the sluggish rate of heterogeneous tri-n-propylamine (TPrA) oxidation. To address this, we investigate the ECL of Ru(ii)-coated microbeads in the presence of a redox mediator, exploring the effect of applied potential and electrode surface terminations. Using a redox mediator, the ECL signal on BDD is enhanced by up to 46-fold.