Regioselective trans-Carboboration of Propargyl Alcohols

Abstract

Proper choice of the base allowed trans-diboration of propargyl alcohols with B 2 (pin) 2 to evolve into an exquisitely regioselective procedure for net trans-carboboration. The method is modular as to the newly introduced carbon substituent (aryl, methyl, allyl, benzyl, alkynyl), which is invariably placed distal to the -OH group.