Catalytic enantioselective addition of Me2Zn to isatins

Abstract

Chiral α-hydroxyamide L5 derived from (S)-(+)-mandelie acid catalyzes the enanlioselective addition of dimelhylzinc lo isatins affording the corresponding chiral 3-hydroxy-3-methyI-2-oxindoles with good yields and er up to 90:10. Furthermore, several chemical transformations were performed with the 3-hydroxy-2-oxindoles obtained.