One-pot, three-component synthesis of fully substituted 1,3,4-oxadiazole derivatives from (N-isocyanoimino)triphenylphosphorane, aromatic carboxylic acids and (1R)-(-)-campherchinon

Abstract

Reactions of (N-isocyanimino)triphenylphosphorane with (1R)-(-)- campherchinon in the presence of aromatic carboxylic acids proceed smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeds smoothly and cleanly under mild conditions and no side reactions were observed.