Malabsorption of Antimycobacterial Medications

Abstract

To the Editor: Malabsorption of antimycobacterial drugs has been reported in one person with AIDS coinfected with Mycobacterium tuberculosis and 26 patients with AIDS coinfected with M. avium complex1–3. We report an additional 32 instances of drug malabsorption in people with AIDS, all but one of whom had tuberculosis. We reviewed the serum concentrations of antimycobacterial drugs in all samples submitted to our laboratory between January 1 and July 31, 1993 (approximately 1100 assays). Serum concentrations were determined primarily by high-performance liquid chromatography or gas chromatography. All assays were extensively validated and were specific for the drugs of . . .