Optimization and comparison of different modes of preparative chromatography

Abstract

Four different modes of preparative chromatography are presented, modeled and compared: classical elution, recycling chromatography, simulated moving bed chromatography and annular chromatography. To describe these modes a uniform model based on the partial differential equations derived from the column mass balances is used. The particularities of each mode are incorporated by specification of proper boundary conditions. Based on experimental data for the separation of two isomers of asteroid compound a quantitative comparison is performed with respect to different objective functions.