Population pharmacokinetic study of aminoglycoside antibiotics in Korean population

Abstract

Background: Aminoglycoside antibiotics are widely used against gram negative infection but careful control of dosage regimen through therapeutic drug monitoring is necessary due to their ototoxicity and nephrotoxicity. We performed a population pharmacokinetic study to evaluate the mean value and distribution of pharmacokinetic parameters of aminoglycoside antibiotics which are essential for therapeutic drug monitoring. Method: 635 adults and 164 children patients' data including drug name, dosage, interval, sampling time, concentration, age, sex, Scr, body weight et al were retrospectively collected from SNU Hospital and analysed by NONMEM program. Result: Amikacin treated adults had clearance about 88% of CLcr with C.V. of 70% and Vd equal to 0.198 x weight (kg) + 1.56 x hematologic malignancy (0 or 1) + 9.0 (L) with C.V. value unobtainable. Amikacin treated children had clearance about 86% of CLcr with C.V. 62%, and Vd of 0.376 x weight (kg) + 0.787 (L) with C.V. 53%. Results of gentamicin, tobramycin treated patients were similar to those of amikacin treated patients. Conclusion: Results of this study provide reference value of pharmacokinetic parameters of aminoglycoside antibiotics in Korean patients and can be applied as basic data for therapeutic drug monitoring of aminoglycoside.