3:3′-diamidinocarbanilide: A new drug active against babesial infections

Abstract

QUINURONIUM sulphate1is the commonly employed treatment for British bovine redwater and a single injection of 1 mgm. of this drug per kgm. of body-weight is effective in a high proportion of cases. But quinuronium sulphate has the disadvantage that even in therapeutic doses it produces toxic effects associated with parasympathetic stimulation. The diamidines, phenamidine and pentamidine, as their di-isethionates, and Berenil are well tolerated and are also used for the treatment of bovine babesiasis, but they are less active than quinuronium sulphate. © 1960 Nature Publishing Group.