Prognostic Role of MicroRNA-200c-141 Cluster in Various Human Solid Malignant Neoplasms

Abstract

The miR-200 family has emerged recently as a noticeable marker for predicting cancer prognosis and tumor progression. We aimed to review the evidence of miR-200c-141 genomic cluster as prognostic biomarkers in cancers. The results suggested that high level of miR-200c had no significant impact on OS (HR = 1.14 [0.77-1.69], P = 0.501) and DFS/PFS (HR = 0.72 [0.45-1.14], P = 0.161). Stratified analyses revealed that high miR-200c expression was significantly related to poor OS in serum/plasma (HR = 2.12 [1.62-2.77], P = 0.000) but not in tissues (HR = 0.89 [0.58-1.37], P = 0.599). High miR-200c expression was significantly associated with favorable DFS/PFS in tissues (HR = 0.56 [0.43-0.73], P = 0.000) but worse DFS/PFS in serum/plasma (HR = 1.90 [1.08-3.36], P = 0.027). For miR-141, we found that high miR-141 expression predicted no significant impact on OS (HR = 1.18 [0.74-1.88], P = 0.482) but poor DFS/PFS (HR = 1.11 [1.04-1.20], P = 0.003). Similarly, subgroup analyses showed that high miR-141 expression predicted poor OS in serum/plasma (HR = 4.34 [2.30-8.21], P = 0.000) but not in tissues (HR = 1.00 [0.92-1.09], P = 0.093). High miR-141 expression was significantly associated with worse DFS/PFS in tissues (HR = 1.12 [1.04-1.20], P = 0.002) but not in serum/plasma (HR = 0.90 [0.44-1.83], P = 0.771). Our findings indicated that, compared to their tissue counterparts, the expression level of miR-200c and miR-141 in peripheral blood may be more effective for monitoring cancer prognosis. High miR-141 expression was better at predicting tumor progression than survival for malignant tumors.