Factors responsible for biomaterials modification in the electron-beam plasma

Abstract

The modification of some biomaterials by the Electron-Beam Plasma was studied experimentally. The powder of the fibrin-monomer (the natural protein which is contained in the blood of mammalians) was treated in the plasma generated by injecting the continuous electron beam in gaseous or vapor media. The fibrin-monomer was found to change its physical-chemical and biological properties due to the treatment. In particular, being modified the fibrin-monomer reduced the human platelet aggregation degree in vitro to 33-35 %, whereas the untreated compound did not inhibit the aggregation. Both experiments and computer simulation were carried out to separate plasmachemical effects from other factors acting on the sample during thee treatment (β-irradiation, UV- and X-ray radiation, heating). The study showed the fibrin-monomer to acquire the anti-aggregation activity due to combined action of all factors mentioned above but the plasmachemical processes are predominant. © 2007 IOP Publishing Ltd.