α-emitters for radiotherapy: From basic radiochemistry to clinical studies—part 1

Abstract

Learning Objectives: On successful completion of this activity, participants should be able to (1) cite α-emitter families available for therapeutic use and understand their current production limit; (2) consider radiation safety concerns when handling α-emitters; and (3) overcome radiolabeling and daughter redistribution hurdles with the approaches described in this educational review. Financial Disclosure: This work is supported by the Radiochemistry and Molecular Imaging Probe Core, which is supported in part by NIH/NCI Cancer Center Support Grant P30 CA008748. Jason Lewis is supported by the Mr. William H. and Mrs. Alice Goodwin and the Commonwealth Foundation for Cancer Research and by the Center for Experimental Therapeutics of Memorial Sloan Kettering Cancer Center. Sophie Poty is supported by the Francxois Wallace Monahan Fellowship from the JLM Benevolent Fund. The authors of this article have indicated no other relevant relationships that could be perceived as a real or apparent conflict of interest. CME Credit: SNMMI is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing education for physicians. SNMMI designates each JNM continuing education article for a maximum of 2.0 AMA PRA Category 1 Credits. Physicians should claim only credit commensurate with the extent of their participation in the activity. For CE credit, SAM, and other credit types, participants can access this activity through the SNMMI website (http://www.snmmilearningcenter.org) through June 2021.