A STUDY OF ANTAGONISTS OF 5‐HYDROXYTRYPTAMINE AND CATECHOL AMINES ON THE RAT'S BLOOD PRESSURE

Abstract

The effects of 5‐hydroxytryptamine on the blood pressure of anaesthetized rats depended on the dose and the initial level of blood pressure. At medium blood pressure levels, 5‐hydroxytryptamine gave a depressor response and sometimes a pressor response which was more evident with large doses. The depressor effect was less apparent or even absent at low, and more pronounced at high, blood pressure levels, and the converse applied to the pressor components. Adenosine also gave a depressor and pressor response. Lysergic acid diethylamide, dihydroergotamine, 1‐(3,4‐dichlorophenyl)‐2‐isopropylaminoethanol (a dichloro analogue of isoprenaline), dibenamine and 1‐benzyl‐5‐methoxy‐2‐methyltryptamine antagonized 5‐hydroxytryptamine and catechol amines. Lysergic acid diethylamide and 1‐benzyl‐5‐methoxy‐2‐methyltryptamine were more effective against 5‐hydroxytryptamine, 1‐(3,4‐dichlorophenyl)‐2‐isopropylaminoethanol and dibenamine against catechol amines; dihydroergotamine was equally effective against both groups. These antagonists fell into two groups according to their action against the two types of effects (depressor and pressor) of 5‐hydroxytryptamine: lysergic acid diethylamide and 1‐(3,4‐dichlorophenyl)‐2‐isopropylaminoethanol acted preferentially against depressor effects; 1‐benzyl‐5‐methoxy‐2‐methyltryptamine and dibenamine preferentially against pressor; dihydroergotamine was not assignable to either group. Adenosine was affected similarly, but less than 5‐hydroxytryptamine. 1960 British Pharmacological Society