Hypnotic activity of brotizolam: a study in general practice.

Abstract

A double‐blind, crossover study was carried out in general practice on the hypnotic activity of 0.25 mg brotizolam in patients aged between 18 and 70 years complaining of insomnia (11 men, 28 women). Patients reported that they slept better, that they awoke less frequently and that they slept longer with brotizolam than with placebo. Overall the patients preferred brotizolam to placebo, and subjective assessments of well‐being after brotizolam did not differ from those after placebo. Brotizolam was well tolerated and there were no incidents of note. 1983 The British Pharmacological Society