Antitumor germacranolides from Anvillea garcinii

Abstract

The aerial parts of Anvillea garcinii yielded two new germacranolides, 9α-hydroxy-1β,10α-epoxyparthenolide (4) and parthenolid-9-one (5), in addition to the known 9α-hydroxyparthenolide (1), 9β-hydroxyparthenolide (2), and 9β-hydroxy-1β,10α-epoxyparthenolide (3). The structures of the new compounds were elucidated from their spectral data (IR, MS, 1H- and 13C-NMR, 1H-1H COSY, and 1H-13C HETCOR) and by chemical derivatization. The hitherto unreported 13C-NMR data and carbon atom assignments of the previously isolated lactones 1, 2, and 3 were given. The in-vitro antitumor and anti-HIV activities were evaluated for the isolated compounds.