Interkinetic nuclear migration

Abstract

A hallmark of neurogenesis in vertebrate is the apical-basal fluctuation of radial glia nuclei. Such a phenomenon called INM has been known for decades and is closely associated with mitosis but still puzzled the scientists. An impressive step in the molecular understanding of INM has recently been achieved by Tsai and coworkers. Using RNA interference associated with time-lapse imaging, these authors demonstrated a dual motor system that can push/pull the nuclei accordingly with the cell cycle stages. © 2011 Landes Bioscience.