Individuelle implantate aus biodegradierbarem kompositmaterial zur versorgung von schädeldefekten

Abstract

For the reconstruction of complex skull defects with individual prefabricated CAD/CAM-implants titanium is well established as a bone substitution material. In this study, a biodegradable composite material from polyesters and calcium phosphate was developed to reduce thermal and psychic stress factors, which were found in previous patient control studies. Biocompatibility tests based on the ISO-standard 10993-5 allowed the choice of suitable materials and showed much better pH-characteristics of the composites in comparison to the pure polymers. For the geometrically precise production of the implants, two different operating procedures (hot pressing and gas flushing) were combined. These implants have already been tested in in-vivo studies in sheep. Two months after implantation, post mortem there was no abnormal histological reaction but signs of beginning bone replacement. Nine months after operation there were no clinical complications in the living animals. © 2004 WILEY-VCH Verlag GmbH & Co. KGaA.