Insulin Resistance in Japanese Adolescents with Type 2 Diabetes Mellitus

Abstract

An oral glucose tolerance test (O-GTT) was conducted in 22 patients with type 2 diabetes mellitus whose ages at onset were less than 18 years old. They were classified into 2 groups, obese and non-obese at onset, and insulin secretory function was compared with that of a non-obese healthy group. The results show that, in the group of obese subjects with type 2 diabetes mellitus, both values of fasting IRI and ∑IRI were significantly higher than those in the healthy group. In the non-obese adolescent group with type 2 diabetes mellitus, both values of fasting IRI and ∑IRI were also significantly higher than those in the healthy group, although the difference was not as prominent as in the obese subjects with type 2 diabetes mellitus. It was revealed that insulin resistance is present not only in obese adolescents with type 2 diabetes mellitus, but also in non-obese adolescents with type 2 diabetes mellitus.