Computer aided planning and navigation for patient-specific deep brain stimulation

Abstract

Deep brain stimulation (DBS) intervention requires demanding planning steps for a precise placement of stimulating electrodes and to ensure the desired clinical result. We present a suite of procedures for computer aided DBS planning and navigation. Central to this development is the automatic extraction of a volumetric target model from magnetic resonance imaging. A two-stage approach is used containing 3D geometric transformations for alignment with a target template and shape refinement using a deformable statistical shape model. The model is then used for simulating the stimulation field and visualizing the optimal electrode position. Microelectrode recordings from test electrodes are analysed to localise their position with respect to the target model. The system has been tested with target subthalamic nucleus for Parkinson disease treatment. © 2013 by Walter de Gruyter.