Abstract
The development of leukemia in donor cells after allogeneic hematopoietic stem cell transplant is an extremely rare event. We report here the case of a patient who developed myelodysplastic syndrome/acute myeloid leukemia, in cells of donor origin 3.5 years after related donor HSCT for refractory chronic lymphocytic leukemia and therapy-induced myelodysplastic syndrome. The origin of the leukemia was determined by analysis of minisatillite polymorphism tested on CD34+ cells.
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Brunstein, C. G., Hirsch, B. A., Hammerschmidt, D., McGlennen, R. C., Nguyen, P. L., & Verfaillie, C. M. (2002). Leukemia in donor cells after allogeneic hematopoietic stem cell transplant. Bone Marrow Transplantation, 29(12), 999–1003. https://doi.org/10.1038/sj.bmt.1703577
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