Visible-light mediated regioselective (phenylsulfonyl)difluoromethylation of fused imidazoles with iododifluoromethyl phenyl sulfone

Abstract

A visible-light catalyzed direct and regioselective (phenylsulfonyl)difluoromethylation of imidazo[1,2-a]pyridines and benzo[d]-imidazo [2,1-b]thiazoles with readily available PhSO2CF2I under mild conditions was developed. This synthetic methodology enables the introduction of a CF2SO2Ph group in an efficient and regioselective reaction through C-H bond functionalization with a broad substrate scope in good to excellent yields.