Vitamin D and hypertension: Prospective study and meta-Analysis

Abstract

Objectives The study sought to determine the link between Vitamin D concentrations and incident hypertension in prospective study and meta-Analysis. Methods The study was embedded in the Kailuan Study, a population-based cohort of adults that contains underground miners. In 2012, we studied 2,456 men and women free of prevalent hypertension, age 21 to 67 at baseline. Serum 25-hydroxyVitamin D was measured from previously frozen baseline samples using ELISA (Enzyme-Linked ImmunoadSorbent Assay). We use the logistic regression analysis to estimate the odd radio (ORs) 95% confidence intervals (CIs) for 25-hydroxyVitamin D [25(OH)D] concentrations with incident hypertension. To help place our new data in context, we conducted a systemic review and metaanalysis of previous prospective reports of Vitamin D and hypertension. Results During a median follow-up of 2 years, 42.6% of the cohort (n = 1047) developed hypertension. Compared with the 25-hydroxyVitamin D >30ng/ml, 25-hydroxyVitamin D <20 ng/ml was associated with a greater hypertension risk (OR: 1.225 [95% CI: 1.010 to 1.485] p = 0.04), although the association was attenuated and not statistically significant after adjusting for potential confounders (OR: 1.092 [95% CI: 0.866 to 1.377] p = 0.456). This meta-Analysis included seven prospective studies for 53,375 participants using adjusted HR founded a significant association between Vitamin D deficiencies and incident hypertension (HRs = 1.235 (95% CI: 1.083 to 1.409, p = 0.002))., , Conclusion Lower serum 25-hydroxyVitamin D concentrations were not associated with a greater risk of incident hypertension. More research is needed to further determine the role of 25-hydroxyVitamin D in hypertension prevention and therapy.