Self-remitting and reversible parkinsonism associated with neuro-sweet disease

Abstract

We describe a 72-year-old man who developed subacute onset parkinsonism caused by neuro-Sweet dis- ease (NSD). Magnetic resonance imaging of this patient's brain suggested inflammation of the bilateral basal ganglia and amygdalae. Clinical symptoms and MRI findings gradually improved without medication. How- ever, his parkinsonism recurred one month after discharge from the hospital, at which time he was treated with corticosteroids, resulting in improvement again. His clinical course and human leukocyte antigen typing suggested that he was suffering from NSD. This case is the first report of NSD presenting with self-remitting and reversible parkinsonism. © 2010 The Japanese Society of Internal Medicine.