Characterization of the radiosensitization effect of pulsed laser ablated-gadolinium

Abstract

Nanomedicine is a field of medical treatment research that has developed rapidly in recent years for the diagnosis and treatment of cancer. New strategies in nanomedicine are to improve cancer diagnosis and therapy at the cellular and molecular level. Materials that are often used for nanomedicine are metal-based gadolinium. This research presents a preliminary study of the radiosensitization properties of gadolinium nanoparticles colloid. Gadolinium nanoparticle colloid was synthesized using a pulsed laser ablation method in pure water. The gadolinium nanoparticle colloid was characterized using a Scanning Electron Microscope and UV-Vis Spectrophotometer. Radiosensitization properties of gadolinium nanoparticles colloid were examined based on the decomposition of x-ray irradiated methylene blue. The results show that gadolinium nanoparticle colloid consists of a spherical shape particle and has a bandgap energy of 5.76 eV. Gadolinium nanoparticle colloid possessed radiosensitization properties with a dose enhancement factor in the range of 1.51-1.54.